The
World Health Organization said Friday that two existing treatments
dramatically reduced deaths from Ebola and should be given to people of all
ages suffering from the often-fatal haemorrhagic disease.
اضافة اعلان
Publishing its first-ever guidelines on which therapeutics to use against
Ebola, the UN health agency strongly recommended using two monoclonal
antibodies, mAb114, also known as Ansuvimab or Ebanga, and REGN-EB3, or
Inmazeb.
Studies had showed that the two treatments significantly "reduced
mortality," Janet Diaz, lead of the clinical management unit in the WHO's
Health Emergencies programme, told reporters in Geneva.
Depending on the standard of care, she said they could save between 230 and 400
lives for every 1,000 people infected.
In its guidelines, the WHO recommended against using other therapeutics that
have been tested for Ebola, including monoclonal antibody ZMapp and antiviral
drug remdesivir.
Ebola is an often-fatal viral haemorrhagic fever that was first identified
in central Africa in 1976. The disease was named after a river in the
Democratic Republic of Congo, then known as Zaire.
The worst epidemic in West Africa between 2013 and 2016 killed more than
11,300 people. The DRC has had more than a dozen epidemics, the deadliest
killing 2,280 people in 2020.
Case fatality rates for the disease, which spreads through bodily fluids and
causes high fever, vomiting and bleeding, can be as high as 80-90 percent,
depending on how quickly it is detected and treated.
The WHO said mAb114 and REGN-EB3 should be given swiftly to anyone who
contracts the virus.
In a statement the health agency said that the two had "demonstrated
clear benefits" and could be used for everyone infected by Ebola, including
older people, pregnant and breastfeeding women, children and newborns.
"Patients should receive recommended neutralising monoclonal antibodies
as soon as possible after laboratory confirmation of diagnosis," it said.
The WHO cautioned though that access to both the treatments remained
"challenging, especially in resource-poor areas."
"WHO is ready to support countries, manufacturers and partners to
improve access to these treatments, and to support national and global efforts
to increase affordability," the UN health agency said.
Robert Fowler of the University of Toronto, who co-chaired the guideline
development group, hailed how "advances in supportive care and
therapeutics over the past decade have revolutionised the treatment of
Ebola."
"Ebola virus disease used to be perceived as a near certain killer.
However, that is no longer the case," he said in the statement.
Combined with proper support, the two recommended treatments mean
"recovery for the vast majority of people," he said.
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